Stendra Dosage

The safety profile of STENDRA allows the flexibility to start patients at mg, and titrate to mg based on individual dosage and tolerability. The exposure 4 hours dosage was lower in subjects with moderate hepatic impairment Child-Pugh B compared to subject with normal hepatic function after mg of avanafil. The safety and efficacy of combinations of Spedra and other Dsage inhibitors or other treatments for erectile dysfunction have not been studied. If the victim has collapsed, had a seizure, has trouble breathing, or can't avanafil awakened, immediately call avanafil services at dosage Hepatic impairment Spedra is contraindicated avanafil patients with severe hepatic impairment Child Pugh class C see sections 4. It is not possible to determine whether these avanafip are related directly to the use of PDE5 inhibitors or to other factors. Continue typing to refine. Thank you for your interest. Latest Update: Some patients experienced a sudden loss of some or all of their vision after they took medications that are similar to avanafil, avanafil dosage. In such circumstances, nitrates should still only be administered under close medical supervision with appropriate haemodynamic monitoring see section 4. Consideration should avvanafil given to the following: Take avanafil exactly as directed. Based on in vitro data, at clinically relevant concentrations avanafil could be an inhibitor of Doaage. Dizziness Somnolence Sinus headache. Please see full Prescribing Information Reference: Many other dosaye may also interact with avanafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. A total of patients avanafil avanafil, which was taken as needed dosage doses of 50 mg one avajafilmg and mg four studiesrespectively.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Stendra Prescribing Information. Print this page Add to My Med List. Avanafil is used to treat erectile dysfunction ED: Priapism has been reported in a small number of post-marketing and clinical trial cases with other PDE5 inhibitors. Adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Maximum dose: About About Drugs. Based on these data avanafil is not anticipated to have a significant effect on other medicinal products metabolised by these enzymes. Availability Prescription only. Date of revision of the text. There was no effect on the extent of exposure AUC. Other treatments for erectile dysfunction The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section 4. Protein binding is independent of total active substance concentrations, age, renal and hepatic function. Also tell your doctor if you have or have ever had retinitis pigmentosa a rare inherited eye disease or if you have ever had severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see. Physicians should discuss with patients the potential for STENDRA to augment the blood pressure-lowering effect of alpha-blockers and other antihypertensive medications.

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Stendra Images. Avanafil does not cure erectile dysfunction or increase sexual desire. In patients receiving concomitant treatment with moderate CYP3A4 inhibitors including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamilthe maximum recommended dose of avanafil should not exceed mg, with an interval of at dosage 48 hours between doses see section dosage. Tablets shown are not actual size. Talk to your doctor about eating grapefruit and drinking grapefruit juice while avanafil this medication. A clinical study was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medicinal products amlodipine and enalapril. Use in patients using other medicinal products Concomitant avanafil of CYP3A4 inhibitors Co-administration of avanafil with avanafil CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin is contraindicated see sections 4. Avanafil is a substrate of and predominantly metabolised by CYP3A4. If you are a patient or customer, please click the "Cancel" button below to return to the previous page. Method of administration For oral use. Spedra 50 mg tablets. Other strong inhibitors of CYP3A4 avanaffil. The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section 4. Stendra Dosage Generic name: Expert Opin Drug Saf. Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension. In the long term clinical study, avanafil dosage, the percentage of patients who experienced adverse reactions decreased with increasing length of exposure. The approximately 20,fold selectivity for PDE5 versus PDE3, and enzyme found in heart and blood vessels, is important because Avansfil is involved in control of cardiac contractility. Patients with known dosaage degenerative retinal disorders. Dosage use of alpha-blockers The concomitant use of alpha-blockers and avanafil may lead to symptomatic hypotension in some patients due to additive vasodilatory effects see section 4. In a patient who has taken avanafil within 12 hours, where nitrate administration is deemed medically necessary in a life-threatening situation, the likelihood of a significant and potentially dangerous drop in blood pressure is increased.

Ask your pharmacist or check the patient information for dosage list of the ingredients. Back to top Dosage. Cardiovascular status Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients since there dosagf a degree of cardiac risk associated with sexual activity see section 4. Single dose of up to mg of avanafil have been given to healthy subjects and multiple daily doses up to mg have been given to patients. Flexible dosing and fewer restrictions 1,2. Availability Prescription only. For oral use. Seasonal allergy. There was no effect of avanafil single dose of avanafil on amlodipine plasma levels. Patients who are using any form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. As a vasodilator, avanafil may reduce systemic blood pressure. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor avanafil that uses outside of the United States are dosagee, unless specifically indicated otherwise. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is also dosage information to carry with you in case of emergencies. Method of administration For oral use. To email a medicine you must sign up and log in. Avanafil may cause other side effects. No cases were reported during clinical trials of avanafil see section 4. Hepatic impairment Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class C see sections 4. Do not let anyone else take avnaafil medication.

Avanafil dosage

Patients with left ventricular outflow obstruction e, avanafil dosage. Other treatments for erectile dysfunction The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section avanafil. Pharmaceutical particulars 6. Not recommended. Avanafil does not cure erectile dysfunction or increase sexual desire. Stendra Rating 45 User Reviews 5, avanafil dosage. Use in patients using other medicinal products Concomitant use of CYP3A4 inhibitors Co-administration of avanafil with potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin is contraindicated see sections avanafil. There was no effect on the extent of exposure AUC. Prolonged erections greater than 4 hours in duration and priapism painful erections greater than 6 hours in duration have been reported with other PDE5 inhibitors. Prescription only medicine. If the victim dosage collapsed, had a seizure, has trouble avanafkl, or can't be awakened, immediately call emergency services at Please see full Prescribing Information. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. This medicinal product does not require any special storage conditions. These exposure changes are not considered clinically significant. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no dosaage is made to avanafil effect. In addition, a subset of patients was enrolled into an open-label extension trial with patients receiving avanafil for at least 6 months and dosage for at least 12 months. Co-administration of avanafil with potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin is contraindicated see sections 4. Older patients 65 years or over had comparable exposure to that seen in younger patients years. Avanafil is rapidly absorbed after oral administration, with a dosage T max of 30 to 45 minutes. Avaanfil Email Updates.

In patients receiving concomitant treatment with moderate CYP3A4 inhibitors including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamilthe maximum recommended dose of avanafil should not exceed mg, with dosage interval of at least 48 hours between doses see section 4. Clinical efficacy and safety In clinical trials, avanafil was assessed for its effect on the ability of men with dosage dysfunction ED to achieve and maintain an erection sufficient for satisfactory sexual activity. Summary of the safety profile The safety profile of Spedra is based on 2, avanafil dosage, subjects exposed to avanafil during the clinical development program. In clinical studies, riociguat has shown to augment the hypotensive effects of PDE5 inhibitors. Flank pain Myalgia Muscle spasms. Drug interactions: Some patients experienced a sudden loss of some or all of their vision after they took medications that are similar to avanafil. Weekly news avanafil. To protect young children from poisoning, always lock safety caps and immediately place the avanafil in a safe location — one that is up and dosage and out of their sight and reach. Availability Prescription only. Subscribe to free Drugs. Effect on dpsage In vitro studies with human platelets indicate that PDE5 inhibitors do not have an effect on platelet aggregation on their own, but at supratherapeutic doses they potentiate the anti-aggregatory effect of the nitric oxide donor sodium nitroprusside. Pharmacodynamic effects Studies in vitro have shown that avanafil is highly selective for PDE5. The use of such combinations is therefore not recommended. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other avanwfil. Do not take more or less of it or take it more often than prescribed by your doctor. Decreased or sudden loss of hearing Patients should be advised to stop taking PDE5 inhibitors, including avanafil, and seek cosage medical attention in the event of sudden decrease or loss of hearing. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Visual defects and cases of avanafjl avanafil ischaemic optic neuropathy NAION have been reported in connection with the intake of other PDE5 inhibitors. Skip to Content. Drug Class.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Ketoconazole mg dailya dosqge and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. Patients with left ventricular outflow obstruction, e. Store it at room temperature and away from excess heat and moisture not in the bathroom. Avanafil may cause side effects. Summary of the safety profile Avamafil safety profile of Spedra is dosage on 2, subjects exposed to avanafil during the clinical development program. Information is also available online at https: FDA alerts for all medications. The recommended starting dose is mg. Dizziness Somnolence Sinus headache. Avanafil to our editorial policy for content sources and attributions. Why is this medication prescribed? Drug Status Rx. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that dowage drug or combination is safe, effective or appropriate for any given patient, avanafil dosage. In a single-dose three-way crossover design dosage evaluating healthy subjects, the mean maximum reduction in diastolic blood pressure was significantly greater following avanafil administered in combination with alcohol than following avanafil alone 3. The exposure 4 hours post-dose avanafiil lower in subjects with dosge hepatic impairment Child-Pugh B compared to subject with normal hepatic function after mg of avanafil.

Usual Adult Dose for Erectile Dysfunction

Monthly newsletter. These exposure changes are not considered clinically significant. We comply with the HONcode standard for trustworthy health information - verify here. These differences were maintained with long term treatment as per dosage in the general ED population, in diabetics with ED and in men with ED following bilateral nerve-sparing radical prostatectomy and in the open-label extension trial. It works by increasing blood flow to the penis during sexual stimulation. Tablets shown are not actual size. In all trials, statistically significant improvement in all primary efficacy measures were observed for all three doses of avanafil compared to placebo. Spedra has minor influence on the ability to drive and use machines. Concomitant use of riociguat with PDE5 inhibitors, including avanafil, is contraindicated see section 4. Cardiac disorders. Stepwise increase in alpha-blocker dose may be avanafil with further lowering of blood pressure when taking avanafil. FDA alerts for all medications. Dyspepsia Nausea Vomiting Stomach discomfort. Rhinorrhoea Upper respiratory tract congestion Epistaxis. FDA alerts for all medications. We comply with the HONcode standard for trustworthy health information - verify here.

By continuing to browse the site you are agreeing to our policy on the use of cookies. Avanafil was not found to accumulate in plasma when dosed mg twice daily over 7 days. Email Address. Patients with known hereditary degenerative retinal disorders. You Are Here: The vision loss was permanent in some cases. In addition, a subset of patients was enrolled into an open-label extension trial with patients receiving avanafil for at least 6 months and patients for at least 12 months. Expert Opin Drug Saf. Other special populations Elderly Older patients 65 years or over had comparable exposure to that seen in younger patients years. Drug Status Rx. Flank pain Myalgia Muscle spasms. A total of patients received avanafil, which was taken as needed at doses of 50 mg one study , mg and mg four studies , respectively. What should I know about storage and disposal of this medication? The maximum recommended dosing frequency is once per day. Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice would likely increase avanafil exposure.

How should this medicine be used?

Tell your doctor if avanafil is not working well or if you experience side effects. Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Visual defects and cases of non-arteritic anterior ischaemic optic neuropathy NAION have been reported in connection with the intake of other PDE5 inhibitors. Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension. When vasodilators are taken in combination, blood pressure-lowering effects of each individual compound may be increased. Across all of the pivotal trials of avanafil, the percentage of successful intercourse attempts was significantly higher for all doses of avanafil compared to placebo for attempts at all post-dosing time intervals examined. Avanafil Rating 47 User Reviews 5. The concomitant use of potent CYP3A4 inhibitors e. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Show table of contents Hide table of contents 1. Prolonged erections greater than 4 hours in duration and priapism painful erections greater than 6 hours in duration have been reported with other PDE5 inhibitors. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. In the Time to onset study, avanafil demonstrated statistically significant improvement in the primary efficacy variable average per subject proportion of successful responses by time after dose administration, to the Sexual Encounter Profile 3 - SEP3 as compared with placebo, resulting in successful intercourse in Avanafil Side Effects. However, data on subjects older than 70 years are limited. Respiratory, thoracic and mediastinal disorders. Co-administration of avanafil with potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin is contraindicated see sections 4. Thank you for your interest. Spedra has minor influence on the ability to drive and use machines. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Call your doctor if you have any unusual problems while taking this medication. Do not take avanafil more often than once in 24 hours. Subscribe to receive email notifications whenever new articles are published. Browse Drugs and Medicines.

Decreased or sudden loss of hearing Patients should be advised to stop taking PDE5 inhibitors, including avanafil, and seek prompt medical attention in the event of sudden decrease or loss of hearing. What should I know about storage and disposal of this medication? Read Next Avanafil Reviews. A phase 3, placebo controlled study of the safety and efficacy of avanafil for the treatment of erectile dysfunction after nerve sparing radical prostatectomy. Before taking avanafil, tell your doctor and pharmacist if you are allergic to avanafil, any other medications, or any of the ingredients in avanafil tablets. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Sinus congestion Dyspnoea exertional. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The use of such combinations is therefore not recommended. Mechanism of action Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. Spedra 50 mg tablets. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Subscribe to receive email notifications whenever new articles are published. Safety and efficacy have not been established in patients younger than 18 years. It works by increasing blood flow to the penis during sexual stimulation. What other information should I know? Pharmacodynamic effects Studies in vitro have shown that avanafil is highly selective for PDE5. Company contact details A. Avanafil may cause other side effects. Physicians should therefore inform patients that substantial consumption of alcohol i. Blood pressure increased Blood urine present Cardiac murmur Prostate specific antigen increased Weight increased Blood bilirubin increased Blood creatinine increased Body temperature increased. The recommended starting dose is mg. Refer to our editorial policy for content sources and attributions. Avanafiil Status Rx. Patients with severe hepatic impairment Child-Pugh C. Dizziness Somnolence Sinus headache. In order for Spedra to be effective, sexual stimulation is required. Continue typing to refine.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Call your doctor if you have any unusual problems while taking this medication. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. Angina pectoris Tachycardia. Also tell your doctor if you have or have ever had retinitis pigmentosa a rare inherited eye disease or if you have ever had severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Based on these data avanafil is not anticipated to have a significant effect on other medicinal products metabolised by these enzymes. Other uses for this medicine. In those patients already taking an optimized dose of a PDE5 inhibitor, alpha-blocker therapy should be initiated at the lowest dose. Print this page Add to My Med List. Although specific interactions of avanafil with rivaroxaban and apixaban both CYP3A4 substrates have not been studied, an interaction is not expected. The exposure 4 hours post-dose was lower in subjects with moderate hepatic impairment Child-Pugh B compared to subject with normal hepatic function after mg of avanafil. Also tell your doctor if you have or have ever had a condition that affects the shape of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease; a heart attack; a stroke; an irregular heartbeat; a blocked artery; angina chest pain ; high or low blood pressure; heart failure; blood cell problems such as sickle cell anemia a disease of the red blood cells , multiple myeloma cancer of the plasma cells , or leukemia cancer of the white blood cells ; ulcers; bleeding problems; or liver or kidney disease. The table below lists the adverse reactions observed in placebo-controlled clinical trials according to the MedDRA frequency convention: Keep all appointments with your doctor. Treatment of erectile dysfunction. We comply with the HONcode standard for trustworthy health avannafil - verify here. The use of avanafil is contraindicated in: To bookmark a medicine you must avanafil up and log in. Medicinal products reducing systemic blood pressure As a vasodilator, avanafil may reduce systemic blood pressure. Refer to our editorial policy for dosage sources and attributions. BasicDescription Back to Top. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy.